3/15/2023 0 Comments Qarc medulloblastoma atlasThe biological equivalent “normalized total dose” (NTD) to the craniospinal axis and the gaps between the three VMAT-treated areas were calculated for α/β-ratio of 2 Gy, and all the data from dose volume histograms (DVHs) are shown.Ĭonclusion: The technique is reliable delivering with safety and accuracy the desirable radiation dose, with biologically and oncologically acceptable dose-deviations within the field-gaps. Three areas of irradiation (cranial, thoracic, and lumbar) were defined, with shifting the gaps between them at a weekly basis (two shifts within the three weeks of therapy). Due to the length of the body areas demanding irradiation, medulloblastoma is a challenging malignancy for the development of advanced radiotherapy techniques.Ĭase Report: We describe a volumetric modulated arc therapy (VMAT) technique applied under image-guided radiation therapy (IGRT) for craniospinal irradiation, offered to a patient with high risk medulloblastoma, together with cisplatin/temozolomide chemotherapy. Michalski JM et al (2016) Results of COG ACNS0331: a phase III trial of involved-field radiotherapy (IFRT) and low dose craniospinal irradiation (LD-CSI) with chemotherapy in average-risk medulloblastoma: a report from the Children’s Oncology Group.Introduction: Adult medulloblastoma is a rare disease. Merchant TE et al (2008) Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. Int J Radiat Oncol Biol Phys 86(2):277–284įranceschi E, Hofer S, Brandes AA et al (2019) EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma. IJROBP 101(1):153–168īrown AP et al (2013) Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma. ![]() Haas-Kogan D et al (2013) National Cancer Institute Workshop on proton therapy for children: considerations regarding brainstem injury. Paulino AC, Lobo M, Teh BS, Okcu MF, South M, Butler EB, Su J, Chintagumpala M (2010) Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma. Lin H, Ding X, Kirk M, Liu H, Zhai H, Hill-Kayser CE, Lustig RA, Tochner Z, Both S, McDonough J (2014) Supine craniospinal irradiation using a proton pencil beam scanning technique without match line changes for field junctions. Radiother Oncol 128(2):192–197Ĭao F, Ramaseshan R, Corns R, Harrop S, Nuraney N, Steiner P, Aldridge S, Liu M, Carolan H, Agranovich A, Karvat A (2012) A three-isocenter jagged-junction IMRT approach for craniospinal irradiation without beam edge matching for field junctions. KeywordsĪjithkumar T et al (2018) SIOPE-brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy. This chapter describes specific directions for inclusion of all areas of CSF and planning pearls. In the 3D conformal era for craniospinal irradiation, these areas were automatically included in the fields. Given this, specific contouring guidelines are important to include the cribriform plate and other foramina that contain cerebrospinal fluid (CSF) with more targeted plans. Overall, given the large volume irradiated, more advanced techniques such as proton therapy, tomotherapy, or IMRT have been utilized to decrease acute and late effects of treatment. Concurrent chemotherapy is sometimes used as well, but this remains controversial with the biggest concern of depressed blood counts given the amount of bone marrow irradiated. ![]() Craniospinal irradiation remains the cornerstone of therapy followed by adjuvant chemotherapy. ![]() Treatment of adults with medulloblastoma is largely based on data regarding the treatment of children.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |